Here are e few problems to work out as an assignment
Assignments due by 9.30 AM, 8th Sept 2005
Problem No.1
Calculate the equilibrium potentials for each of the ions and the resting membrane potential for a cardiac muscle cell from the data given below. Is the calculated value in the normal range for a cardiac muscle
Na+ in ECF: 145mMol/L; Na+ in ICF: 12mMol/L, Permeability for Na+:1; K+ in ECF:4; K+ in ICF: 155mMol/L;Permeability for K+:200; Cl- in ECF: 120mMol/L; Cl- in ICF: 3.8mMol/L, Permeability for Cl: 100
Problem No.2
A person develops a severe renal disease. As a result he is unable to excrete the normal amounts of and Na+ and K+ from her plasma and they accumulate to levels of 160mMol/L (Na+) and 9.0mMol/L (K+).
Assuming that all other values remain the same as in Problem No.1, predict the change in resting membrane potential from normal. Explain your observations.
She was treated to correct the Na+ concentration normal to levels. However the K+ level remained at 9mMol/L. What is the new RMP? Has it changed much? Explain your observations
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